SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations

To elucidate whether tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia is associated with characteristic genomic alterations, we analyzed DNA samples from 45 TKI-resistant chronic myeloid leukemia patients with 250K single nucleotide polymorphism arrays. From 20 patients, matche...

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Detalhes bibliográficos
Main Authors: Nowak, Daniel, Ogawa, Seishi, Müschen, Markus, Kato, Motohiro, Kawamata, Norihiko, Meixel, Antonie, Nowak, Verena, Kim, Han S., Kang, Sharon, Paquette, Ronald, Chang, Mi-Sook, Thoenissen, Nils H., Mossner, Max, Hofmann, Wolf-Karsten, Kohlmann, Alexander, Weiss, Tamara, Haferlach, Torsten, Haferlach, Claudia, Koeffler, H. Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817631/
https://ncbi.nlm.nih.gov/pubmed/19965645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-210377
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