"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.

The trypanosomatid flavoprotein disulfide reductase, trypanothione reductase, is shown to catalyze one-electron reduction of suitably substituted naphthoquinone and nitrofuran derivatives. A number of such compounds have been chemically synthesized, and a structure-activity relationship has been est...

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Main Authors: Henderson, G B, Ulrich, P, Fairlamb, A H, Rosenberg, I, Pereira, M, Sela, M, Cerami, A
Format: Artigo
Jezik:Inglês
Izdano: 1988
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC281759/
https://ncbi.nlm.nih.gov/pubmed/3135548
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