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"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.

The trypanosomatid flavoprotein disulfide reductase, trypanothione reductase, is shown to catalyze one-electron reduction of suitably substituted naphthoquinone and nitrofuran derivatives. A number of such compounds have been chemically synthesized, and a structure-activity relationship has been est...

詳細記述

保存先:
書誌詳細
主要な著者: Henderson, G B, Ulrich, P, Fairlamb, A H, Rosenberg, I, Pereira, M, Sela, M, Cerami, A
フォーマット: Artigo
言語:Inglês
出版事項: 1988
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC281759/
https://ncbi.nlm.nih.gov/pubmed/3135548
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