Unexpected Tolerance of α-Cleavage of the Prion Protein to Sequence Variations

The cellular form of the prion protein, PrP(C), undergoes extensive proteolysis at the α site (109K↓H110). Expression of non-cleavable PrP(C) mutants in transgenic mice correlates with neurotoxicity, suggesting that α-cleavage is important for PrP(C) physiology. To gain insights into the mechanisms...

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Autori principali: Oliveira-Martins, José B., Yusa, Sei-ichi, Calella, Anna Maria, Bridel, Claire, Baumann, Frank, Dametto, Paolo, Aguzzi, Adriano
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817006/
https://ncbi.nlm.nih.gov/pubmed/20161712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009107
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