Unexpected Tolerance of α-Cleavage of the Prion Protein to Sequence Variations

The cellular form of the prion protein, PrP(C), undergoes extensive proteolysis at the α site (109K↓H110). Expression of non-cleavable PrP(C) mutants in transgenic mice correlates with neurotoxicity, suggesting that α-cleavage is important for PrP(C) physiology. To gain insights into the mechanisms...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Oliveira-Martins, José B., Yusa, Sei-ichi, Calella, Anna Maria, Bridel, Claire, Baumann, Frank, Dametto, Paolo, Aguzzi, Adriano
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817006/
https://ncbi.nlm.nih.gov/pubmed/20161712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009107
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki