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Unexpected Tolerance of α-Cleavage of the Prion Protein to Sequence Variations
The cellular form of the prion protein, PrP(C), undergoes extensive proteolysis at the α site (109K↓H110). Expression of non-cleavable PrP(C) mutants in transgenic mice correlates with neurotoxicity, suggesting that α-cleavage is important for PrP(C) physiology. To gain insights into the mechanisms...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2817006/ https://ncbi.nlm.nih.gov/pubmed/20161712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009107 |
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