Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

BACKGROUND: Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer as well as tumor angiogenesis, making...

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Hauptverfasser: Aste-Amézaga, Miguel, Zhang, Ningyan, Lineberger, Janet E., Arnold, Beth A., Toner, Timothy J., Gu, Mingcheng, Huang, Lingyi, Vitelli, Salvatore, Vo, Kim T., Haytko, Peter, Zhao, Jing Zhang, Baleydier, Frederic, L'Heureux, Sarah, Wang, Hongfang, Gordon, Wendy R., Thoryk, Elizabeth, Andrawes, Marie Blanke, Tiyanont, Kittichoat, Stegmaier, Kimberly, Roti, Giovanni, Ross, Kenneth N., Franlin, Laura L., Wang, Hui, Wang, Fubao, Chastain, Michael, Bett, Andrew J., Audoly, Laurent P., Aster, Jon C., Blacklow, Stephen C., Huber, Hans E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817004/
https://ncbi.nlm.nih.gov/pubmed/20161710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009094
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