Distinct expression profiles of Notch-1 protein in human solid tumors: Implications for development of targeted therapeutic monoclonal antibodies

Biological therapies, such as monoclonal antibodies (mAbs) that target tumor-associated antigens have been considered an effective therapeutic approach in oncology. In considering Notch-1 receptor as a potential target, we performed immunohistochemistry on tissue microarrays to determine 1) whether...

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Bibliographic Details
Main Authors: Li, Yuan, Burns, Janine A, Cheney, Carol A, Zhang, Ningyan, Vitelli, Salvatore, Wang, Fubao, Bett, Andrew, Chastain, Michael, Audoly, Laurent P, Zhang, Zhi-Qiang
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2010
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898104/
https://ncbi.nlm.nih.gov/pubmed/20631820
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