Osteoblasts and Bone Marrow Mesenchymal Stromal Cells Control Hematopoietic Stem Cell Migration and Proliferation in 3D In Vitro Model

BACKGROUND: Migration, proliferation, and differentiation of hematopoietic stem cells (HSCs) are dependent upon a complex three-dimensional (3D) bone marrow microenvironment. Although osteoblasts control the HSC pool, the subendosteal niche is complex and its cellular composition and the role of eac...

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Detalhes bibliográficos
Main Authors: de Barros, Ana Paula D. N., Takiya, Christina M., Garzoni, Luciana R., Leal-Ferreira, Mona Lisa, Dutra, Hélio S., Chiarini, Luciana B., Meirelles, Maria Nazareth, Borojevic, Radovan, Rossi, Maria Isabel D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816998/
https://ncbi.nlm.nih.gov/pubmed/20161704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009093
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