Melanoma Cells Treated with GGTI and IFN-γ Allow Murine Vaccination and Enhance Cytotoxic Response against Human Melanoma Cells

BACKGROUND: Suboptimal activation of T lymphocytes by melanoma cells is often due to the defective expression of class I major histocompatibility antigens (MHC-I) and costimulatory molecules. We have previously shown that geranylgeranyl transferase inhibition (done with GGTI-298) stimulates anti-mel...

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Main Authors: Sarrabayrouse, Guillaume, Pich, Christine, Moriez, Raphaël, Armand-Labit, Virginie, Rochaix, Philippe, Favre, Gilles, Tilkin-Mariamé, Anne-Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815789/
https://ncbi.nlm.nih.gov/pubmed/20140259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009043
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