Paradoxical down-regulation of p16(INK4a) mRNA with advancing age in Acute Myeloid Leukemia

Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence. An important effector of aging is the cyclindependent kinase inhibitor p16(INK4a), which is al...

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Bibliographic Details
Main Authors: de Jonge, Hendrik J.M., Woolthuis, Carolien M., de Bont, Eveline S.J.M., Huls, Gerwin
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2009
Subjects:
Research Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815746/
https://ncbi.nlm.nih.gov/pubmed/20157576
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