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Paradoxical down-regulation of p16(INK4a) mRNA with advancing age in Acute Myeloid Leukemia

Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence. An important effector of aging is the cyclindependent kinase inhibitor p16(INK4a), which is al...

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Detalhes bibliográficos
Main Authors: de Jonge, Hendrik J.M., Woolthuis, Carolien M., de Bont, Eveline S.J.M., Huls, Gerwin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815746/
https://ncbi.nlm.nih.gov/pubmed/20157576
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