Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery

Mammalian ferrochelatase, the terminal enzyme in the heme biosynthetic pathway, possesses an iron-sulfur [2Fe-2S] cluster that does not participate in catalysis. We investigated ferrochelatase expression in iron-deficient erythropoietic tissues of mice lacking iron regulatory protein 2, in iron-defi...

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Bibliographic Details
Main Authors: Crooks, Daniel R., Ghosh, Manik C., Haller, Ronald G., Tong, Wing-Hang, Rouault, Tracey A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815515/
https://ncbi.nlm.nih.gov/pubmed/19965627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-243105
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