Thiopurine S-Methyltransferase Pharmacogenetics: Functional Characterization of a Novel Rapidly Degraded Variant Allozyme

A novel human thiopurine S-methyltransferase (TPMT) variant allele, (319 T>G, 107 Tyr>Asp, *27), was identified in a Thai renal transplantation recipient with reduced erythrocyte TPMT activity. The TPMT*27 variant allozyme showed a striking decrease in both immunoreactive protein level and enz...

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Autori principali: Feng, Qiping, Vannaprasaht, Suda, Peng, Yi, Angsuthum, Susothorn, Avihingsanon, Yingyos, Yee, Vivien C., Tassaneeyakul, Wichittra, Weinshilboum, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815203/
https://ncbi.nlm.nih.gov/pubmed/19945438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.11.016
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