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Structural Bases for Stability-Function Tradeoffs in Antibiotic Resistance
Pre-organization of enzyme active sites for substrate recognition typically comes at a cost to the stability of the folded form of the protein, and consequently enzymes can be dramatically stabilized by substitutions that attenuate the size and pre-organization “strain” of the active site. How this...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2815101/ https://ncbi.nlm.nih.gov/pubmed/19913034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.11.005 |
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