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Re-examining the role of Lys67 in class C β-lactamase catalysis
Lys67 is essential for the hydrolysis reaction mediated by class C β-lactamases. Its exact catalytic role lies at the center of several different proposed reaction mechanisms, particularly for the deacylation step, and has been intensely debated. Whereas a conjugate base hypothesis postulates that a...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760372/ https://ncbi.nlm.nih.gov/pubmed/19241376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.60 |
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