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Mechanism of proton transfer in class A β-lactamase catalysis and inhibition by avibactam
Gram-negative bacteria expressing class A β-lactamases pose a serious health threat due to their ability to inactivate all β-lactam antibiotics. The acyl–enzyme intermediate is a central milestone in the hydrolysis reaction catalyzed by these enzymes. However, the protonation states of the catalytic...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7084157/ https://ncbi.nlm.nih.gov/pubmed/32123084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922203117 |
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