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Mechanisms of Proton Relay and Product Release by Class A β-Lactamase at Ultrahigh Resolution
The β-lactam antibiotics inhibit penicillin-binding proteins (PBPs) by forming a stable, covalent, acyl-enzyme complex. During the evolution from PBPs to Class A β-lactamases, the β-lactamases acquired Glu166 to activate a catalytic water and cleave the acyl-enzyme bond. Here we present three produc...
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| Publicado no: | FEBS J |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5760336/ https://ncbi.nlm.nih.gov/pubmed/29095570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14315 |
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