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Identification of residues critical for catalysis in a class C β-lactamase by combinatorial scanning mutagenesis
Despite their clinical importance, the mechanism of action of the class C β-lactamases is poorly understood. In contrast to the class A and class D β-lactamases, which contain a glutamate residue and a carbamylated lysine in their respective active sites that are thought to serve as general base cat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323950/ https://ncbi.nlm.nih.gov/pubmed/12876313 |
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