Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions

Oxidative stress and aggregation of the presynaptic protein α-synuclein (α-Syn) are implied in the pathogenesis of Parkinson disease and several other neurodegenerative diseases. Various posttranslational modifications, such as oxidation, nitration and truncation, have significant effects on the kin...

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Main Authors: Zhou, Wenbo, Long, Chunmei, Reaney, Stephen H., Di Monte, Donato A., Fink, Anthony L., Uversky, Vladimir N.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814895/
https://ncbi.nlm.nih.gov/pubmed/20026206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2009.12.004
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