Determination of Nutlin-3a in Murine Plasma by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS)

A sensitive and precise LC-ESI-MS/MS method for determination of nutlin-3a in murine plasma using ketoconazole as an internal standard was developed and validated. Plasma nutlin-3a samples were prepared by either a simple protein precipitation (PP) for the high concentration range (10 – 20,000 ng/mL...

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Главные авторы: Bai, Feng, Zhu, Fangyi, Tagen, Michael, Miller, Laura, Owens, Thandranese S., Mallari, Jeremy, Derrick, Edward, Zhang, Fan, Stewart, Clinton F.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814893/
https://ncbi.nlm.nih.gov/pubmed/19931997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2009.10.016
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