Grb7 Upregulation Is a Molecular Adaptation to HER2 Signaling Inhibition Due to Removal of Akt-Mediated Gene Repression

The efficacy of anti-HER2 therapeutics, such as lapatinib and trastuzumab, is limited by primary and acquired resistance. Cellular adaptations that allow breast cancer cell to survive prolonged HER2 inhibition include de-repression of the transcription factor FOXO3A with consequent estrogen receptor...

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Detalhes bibliográficos
Main Authors: Nencioni, Alessio, Cea, Michele, Garuti, Anna, Passalacqua, Mario, Raffaghello, Lizzia, Soncini, Debora, Moran, Eva, Zoppoli, Gabriele, Pistoia, Vito, Patrone, Franco, Ballestrero, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814867/
https://ncbi.nlm.nih.gov/pubmed/20126311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009024
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