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Controlling hydrogen scrambling in multiply charged protein ions during collisional activation: Implications for top-down HDX MS utilizing collisional activation in the gas phase
Hydrogen exchange in solution combined with ion fragmentation in the gas phase followed by MS detection emerged in recent years as a powerful tool to study higher order protein structure and dynamics. However, certain type of ion chemistry in the gas phase, namely internal rearrangement of labile hy...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2813994/ https://ncbi.nlm.nih.gov/pubmed/20055445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac9021874 |
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