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Cardiac Overexpression of Metallothionein Rescues Cardiac Contractile Dysfunction and Endoplasmic Reticulum Stress But Not Autophagy in Sepsis

Sepsis is characterized by systematic inflammation where oxidative damage plays a key role in organ failure. This study was designed to examine the impact of the antioxidant metallothionein (MT) on lipopolysaccharide (LPS)-induced cardiac contractile and intracellular Ca(2+) dysfunction, oxidative s...

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Main Authors: Ceylan-Isik, Asli F., Zhao, Peng, Zhang, Bingfang, Xiao, Xiaoyan, Su, Guohai, Ren, Jun
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813369/
https://ncbi.nlm.nih.gov/pubmed/19914257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.11.003
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