Peloruside B, a Potent Antitumor Macrolide from the New Zealand Marine Sponge Mycale hentscheli: Isolation, Structure, Total Synthesis and Bioactivity

Peloruside B (2), a natural congener of peloruside A (1), was isolated in sub-milligram quantities from the New Zealand marine sponge Mycale hentscheli. Peloruside B promotes microtubule polymerization and arrests cells in the G(2)M phase of mitosis similar to paclitaxel, and its bioactivity was com...

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Main Authors: Singh, A. Jonathan, Xu, Chun-Xiao, Xu, Xiaoming, West, Lyndon M., Wilmes, Anja, Chan, Ariane, Hamel, Ernest, Miller, John H., Northcote, Peter T., Ghosh, Arun K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812918/
https://ncbi.nlm.nih.gov/pubmed/19957922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo9021265
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