Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening

Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematologic malignancies. A somatic mutation of JAK2 (Val617Phe) was previously shown to occur in 98% of patients with polycythemia vera and 50% of patients with essential thrombocythemia and primary...

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Main Authors: Kiss, Róbert, Polgár, Tímea, Kirabo, Annet, Sayyah, Jacqueline, Figueroa, Nicholas C., List, Alan F., Sokol, Lubomir, Zuckerman, Kenneth S., Gali, Meghanath, Bisht, Kirpal S., Sayeski, Peter P., Keserű, György M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812898/
https://ncbi.nlm.nih.gov/pubmed/19447617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.04.138
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