Catechol-O-methyltransferase Val(158)Met Genotype and Resting Regional Cerebral Blood Flow in Medication-Free Patients with Schizophrenia

BACKGROUND: A valine(158)methionine polymorphism in Catechol-O-methyltransferase (COMT) modulates cortical dopaminergic catabolism and has been associated with schizophrenia. Consistent with schizophrenia itself, during cognitive tasks, the risk (val) allele predicts less efficient prefrontal cortex...

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Hlavní autoři: Eisenberg, Daniel Paul, Sarpal, Deepak, Kohn, Philip D., Meyer-Lindenberg, Andreas, Wint, Dylan, Kolachana, Bhaskar, Apud, José, Weinberger, Daniel R., Berman, Karen Faith
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812618/
https://ncbi.nlm.nih.gov/pubmed/19892319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2009.08.039
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