Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

Autoreactive B lymphocytes first encountering self-antigens in peripheral tissues are normally regulated by induction of anergy or apoptosis. According to the “two-signal” model, antigen recognition alone should render B cells tolerant unless T cell help or inflammatory signals such as lipopolysacch...

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Bibliografiske detaljer
Main Authors: Duong, Bao Hoa, Tian, Hua, Ota, Takayuki, Completo, Gladys, Han, Shoufa, Vela, José Luis, Ota, Miyo, Kubitz, Michael, Bovin, Nicolai, Paulson, James C., Nemazee, David
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812539/
https://ncbi.nlm.nih.gov/pubmed/20038598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091873
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