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Liver-expressed Igκ superantigen induces tolerance of polyclonal B cells by clonal deletion not κ to λ receptor editing

Little is know about the nature of peripheral B cell tolerance or how it may vary in distinct lineages. Although autoantibody transgenic studies indicate that anergy and apoptosis are involved, some studies claim that receptor editing occurs. To model peripheral B cell tolerance in a normal, polyclo...

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Hlavní autoři: Ota, Takayuki, Ota, Miyo, Duong, Bao Hoa, Gavin, Amanda L., Nemazee, David
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058582/
https://ncbi.nlm.nih.gov/pubmed/21357741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102265
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