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Recombination by the mouse immunoglobulin κ deleting element RS promotes immune tolerance and Igλ B cell production

The recombining sequence (RS) of mouse and its human equivalent, the kappa deleting element (kde), are sequences found at the 3′ end of the immunoglobulin κ locus that rearrange to inactivate the κ-locus in developing B cells. RS recombination correlates with Igλ expression and plays a role in recep...

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Detalhes bibliográficos
Main Authors: Vela, José Luis, Aït-Azzouzene, Djemel, Duong, Bao Hoa, Ota, Takayuki, Nemazee, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2351955/
https://ncbi.nlm.nih.gov/pubmed/18261939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.12.011
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