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Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets

Chaperonins are key components of the cellular chaperone machinery. These large, cylindrical complexes contain a central cavity that binds to unfolded polypeptides and sequesters them from the cellular environment. Substrate folding then occurs in this central cavity in an ATP-dependent manner. The...

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Main Authors: Spiess, Christoph, Meyer, Anne S., Reissmann, Stefanie, Frydman, Judith
Formato: Artigo
Idioma:Inglês
Publicado: 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812437/
https://ncbi.nlm.nih.gov/pubmed/15519848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2004.09.015
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