Identification of Hydroxywarfarin Binding Site in Human UDP Glucuronosyltransferase 1A10: Phenylalanine(90) Is Crucial for the Glucuronidation of 6- and 7-Hydroxywarfarin but Not 8-Hydroxywarfarin

Recent studies show that the extrahepatic human UDP-glucurono-syltransferase (UGT)1A10 is capable of phase II glucuronidation of several major cytochrome P450 metabolites of warfarin (i.e., 6-, 7-, and 8-hydroxywarfarin). This study expands on this finding by testing the hypothesis that the UGT1A10...

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Main Authors: Miller, Grover P., Lichti, Cheryl F., Zielinska, Agnieszka K., Mazur, Anna, Bratton, Stacie M., Gallus-Zawada, Anna, Finel, Moshe, Moran, Jeffery H., Radominska-Pandya, Anna
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812427/
https://ncbi.nlm.nih.gov/pubmed/18725508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022863
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