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Leflunomide Inhibition of BK Virus Replication in Renal Tubular Epithelial Cells

The immunomodulatory drug leflunomide is frequently used for treating polyomavirus-associated nephropathy, yet its antiviral mechanism is unclear. We characterized the effects of the active leflunomide metabolite A771726 (LEF-A) on the polyomavirus BK (BKV) life cycle in human renal tubular epitheli...

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Main Authors: Bernhoff, Eva, Tylden, Garth D., Kjerpeseth, Lars J., Gutteberg, Tore J., Hirsch, Hans H., Rinaldo, Christine H.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812362/
https://ncbi.nlm.nih.gov/pubmed/19955306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01737-09
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