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Cell Cycle Arrest by Transforming Growth Factor β1 near G(1)/S Is Mediated by Acute Abrogation of Prereplication Complex Activation Involving an Rb-MCM Interaction
Understanding inhibitory mechanisms of transforming growth factor β1 (TGF-β1) has provided insight into cell cycle regulation and how TGF-β1 sensitivity is lost during tumorigenesis. We show here that TGF-β1 utilizes a previously unknown mechanism targeting the function of prereplication complexes (...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2812244/ https://ncbi.nlm.nih.gov/pubmed/19948884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01152-09 |
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