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Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways
The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of G1 cell cycle progression. Two key substrates of mTORC1 are ribosomal subunit S6 kinase (S6K) and eukaryotic initiation factor 4E (eIF4E) binding protein-1 (4E-BP1). We reported previously that simultaneous knockdown of...
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| Publicado no: | Cancer Lett |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4415112/ https://ncbi.nlm.nih.gov/pubmed/25659819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.01.043 |
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