Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways

The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of G1 cell cycle progression. Two key substrates of mTORC1 are ribosomal subunit S6 kinase (S6K) and eukaryotic initiation factor 4E (eIF4E) binding protein-1 (4E-BP1). We reported previously that simultaneous knockdown of...

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Bibliografiska uppgifter
I publikationen:Cancer Lett
Huvudupphovsmän: Chatterjee, Amrita, Mukhopadhyay, Suman, Tung, Kaity, Patel, Deven, Foster, David A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415112/
https://ncbi.nlm.nih.gov/pubmed/25659819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.01.043
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