Epitope Switching as a Novel Escape Mechanism of HIV to CCR5 Monoclonal Antibodies

In passaging experiments, we isolated HIV strains resistant to MAb3952, a chemokine (C-C motif) receptor 5 (CCR5) monoclonal antibody (MAb) that binds to the second extracellular domain (extracellular loop 2 [ECL-2]) of CCR5. MAb3952-resistant viruses remain CCR5-tropic and are cross-resistant to a...

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Bibliographische Detailangaben
Hauptverfasser: Jekle, Andreas, Chhabra, Milloni, Lochner, Adriane, Meier, Sonja, Chow, Eugene, Brandt, Michael, Sankuratri, Surya, Cammack, Nick, Heilek, Gabrielle
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812136/
https://ncbi.nlm.nih.gov/pubmed/19995923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00841-09
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