Development of Tetravalent, Bispecific CCR5 Antibodies with Antiviral Activity against CCR5 Monoclonal Antibody-Resistant HIV-1 Strains

In this study, we describe novel tetravalent, bispecific antibody derivatives that bind two different epitopes on the HIV coreceptor CCR5. The basic protein formats that we applied were derived from Morrison-type bispecific antibodies: whole IgGs to which we connected single-chain antibodies (scFvs)...

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Detalles Bibliográficos
Main Authors: Schanzer, Jürgen, Jekle, Andreas, Nezu, Junichi, Lochner, Adriane, Croasdale, Rebecca, Dioszegi, Marianna, Zhang, Jun, Hoffmann, Eike, Dormeyer, Wilma, Stracke, Jan, Schäfer, Wolfgang, Ji, Changhua, Heilek, Gabrielle, Cammack, Nick, Brandt, Michael, Umana, Pablo, Brinkmann, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088204/
https://ncbi.nlm.nih.gov/pubmed/21300827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00215-10
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