Development of Tetravalent, Bispecific CCR5 Antibodies with Antiviral Activity against CCR5 Monoclonal Antibody-Resistant HIV-1 Strains

In this study, we describe novel tetravalent, bispecific antibody derivatives that bind two different epitopes on the HIV coreceptor CCR5. The basic protein formats that we applied were derived from Morrison-type bispecific antibodies: whole IgGs to which we connected single-chain antibodies (scFvs)...

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書誌詳細
主要な著者: Schanzer, Jürgen, Jekle, Andreas, Nezu, Junichi, Lochner, Adriane, Croasdale, Rebecca, Dioszegi, Marianna, Zhang, Jun, Hoffmann, Eike, Dormeyer, Wilma, Stracke, Jan, Schäfer, Wolfgang, Ji, Changhua, Heilek, Gabrielle, Cammack, Nick, Brandt, Michael, Umana, Pablo, Brinkmann, Ulrich
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2011
主題:
Antiviral Agents
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088204/
https://ncbi.nlm.nih.gov/pubmed/21300827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00215-10
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