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Epitope Switching as a Novel Escape Mechanism of HIV to CCR5 Monoclonal Antibodies
In passaging experiments, we isolated HIV strains resistant to MAb3952, a chemokine (C-C motif) receptor 5 (CCR5) monoclonal antibody (MAb) that binds to the second extracellular domain (extracellular loop 2 [ECL-2]) of CCR5. MAb3952-resistant viruses remain CCR5-tropic and are cross-resistant to a...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2812136/ https://ncbi.nlm.nih.gov/pubmed/19995923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00841-09 |
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