Protein interactions involving the γ2 large cytoplasmic loop of GABA(A) receptors modulate conductance

Native GABA(A) channels display a single-channel conductance ranging between ∼10 and 90 pS. Diazepam increases the conductance of some of these native channels but never those of recombinant receptors, unless they are coexpressed with GABARAP. This trafficking protein clusters recombinant receptors...

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Detalhes bibliográficos
Main Authors: Everitt, Andrea B., Seymour, Victoria A. L., Curmi, John, Laver, Derek R., Gage, Peter W., Tierney, M. Louise
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812045/
https://ncbi.nlm.nih.gov/pubmed/19703932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-137042
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