Protein interactions involving the γ2 large cytoplasmic loop of GABA(A) receptors modulate conductance

Native GABA(A) channels display a single-channel conductance ranging between ∼10 and 90 pS. Diazepam increases the conductance of some of these native channels but never those of recombinant receptors, unless they are coexpressed with GABARAP. This trafficking protein clusters recombinant receptors...

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Bibliographic Details
Main Authors: Everitt, Andrea B., Seymour, Victoria A. L., Curmi, John, Laver, Derek R., Gage, Peter W., Tierney, M. Louise
Format: Artigo
Language:Inglês
Published: The Federation of American Societies for Experimental Biology 2009
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812045/
https://ncbi.nlm.nih.gov/pubmed/19703932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-137042
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