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HIV-1 Tat regulates cyclin B1 by promoting both expression and degradation

Cyclin B1, an important cell cycle regulator, was up-regulated in lymphocytes of human immunodeficiency virus (HIV)-infected patients. However, the mechanism of cyclin B1 up-regulation and the effects of the up-regulation on the host cells remain unclear. Here, we show that HIV-encoded Tat protein r...

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Autors principals: Zhang, Shi-Meng, Sun, Yi, Fan, Rong, Xu, Qin-Zhi, Liu, Xiao-Dan, Zhang, Xiangming, Wang, Ya, Zhou, Ping-Kun
Format: Artigo
Idioma:Inglês
Publicat: The Federation of American Societies for Experimental Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812038/
https://ncbi.nlm.nih.gov/pubmed/19825974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-143925
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