Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat

BACKGROUND: The positive transcription elongation factor b (P-TEFb) is an essential cellular co-factor for the transcription of the human immunodeficiency virus type 1 (HIV-1). The cyclin T1 (CycT1) subunit of P-TEFb associates with a viral protein, Tat, at the transactivation response element (TAR)...

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Detalhes bibliográficos
Main Authors: Jadlowsky, Julie K, Nojima, Masanori, Schulte, Antje, Geyer, Matthias, Okamoto, Takashi, Fujinaga, Koh
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492875/
https://ncbi.nlm.nih.gov/pubmed/18620576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-5-63
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