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Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.

Human cyclin T1 (hCycT1), a major subunit of the essential elongation factor P-TEFb, has been proposed to act as a cofactor for human immunodeficiency virus type 1 (HIV-1) Tat. Here, we show that murine cyclin T1 (mCycT1) binds the activation domain of HIV-1 Tat but, unlike hCycT1, cannot mediate Ta...

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Bibliografiske detaljer
Main Authors: Bieniasz, P D, Grdina, T A, Bogerd, H P, Cullen, B R
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171053/
https://ncbi.nlm.nih.gov/pubmed/9843510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.23.7056
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