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Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats

BACKGROUND AND PURPOSE: FTY720 is a known sphingosine-1-phosphate (S1P) receptor agonist. In the present study we investigated the neuroprotective effect of postischemic administration of FTY720 in rats with 2 hours transient middle cerebral artery occlusion (MCAO). METHODS: One hundred eleven male...

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Bibliografiske detaljer
Main Authors: Hasegawa, Yu, Suzuki, Hidenori, Sozen, Takumi, Rolland, William, Zhang, John H
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811754/
https://ncbi.nlm.nih.gov/pubmed/19940275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.109.568899
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