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Radioprotection in Normal Tissue and Delayed Tumor Growth by Blockade of CD47 Signaling

Radiation-induced damage of normal tissues restricts the therapeutic doses of ionizing radiation that can be delivered to tumors and thereby limits the effectiveness of radiotherapy. Thrombospondin-1 signaling through its cell surface receptor CD47 limits recovery from several types of stress, and m...

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Detalhes bibliográficos
Main Authors: Maxhimer, Justin B., Soto-Pantoja, David R., Ridnour, Lisa A, Shih, Hubert B., DeGraff, William G., Tsokos, Maria, Wink, David A., Isenberg, Jeff S., Roberts, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811586/
https://ncbi.nlm.nih.gov/pubmed/20161613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000139
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