Thrombospondin-1 and CD47 Limit Cell and Tissue Survival of Radiation Injury

Radiation, a primary mode of cancer therapy, acutely damages cellular macromolecules and DNA and elicits stress responses that lead to cell death. The known cytoprotective activity of nitric oxide (NO) is blocked by thrombospondin-1, a potent antagonist of NO/cGMP signaling in ischemic soft tissues,...

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Detalhes bibliográficos
Main Authors: Isenberg, Jeff S., Maxhimer, Justin B., Hyodo, Fuminori, Pendrak, Michael L., Ridnour, Lisa A., DeGraff, William G., Tsokos, Maria, Wink, David A., Roberts, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543077/
https://ncbi.nlm.nih.gov/pubmed/18787106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.080237
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