Thrombospondin-1 and CD47 Limit Cell and Tissue Survival of Radiation Injury

Radiation, a primary mode of cancer therapy, acutely damages cellular macromolecules and DNA and elicits stress responses that lead to cell death. The known cytoprotective activity of nitric oxide (NO) is blocked by thrombospondin-1, a potent antagonist of NO/cGMP signaling in ischemic soft tissues,...

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Hlavní autoři: Isenberg, Jeff S., Maxhimer, Justin B., Hyodo, Fuminori, Pendrak, Michael L., Ridnour, Lisa A., DeGraff, William G., Tsokos, Maria, Wink, David A., Roberts, David D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2008
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543077/
https://ncbi.nlm.nih.gov/pubmed/18787106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.080237
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