Thrombospondin-1 and CD47 Limit Cell and Tissue Survival of Radiation Injury

Radiation, a primary mode of cancer therapy, acutely damages cellular macromolecules and DNA and elicits stress responses that lead to cell death. The known cytoprotective activity of nitric oxide (NO) is blocked by thrombospondin-1, a potent antagonist of NO/cGMP signaling in ischemic soft tissues,...

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Autori principali: Isenberg, Jeff S., Maxhimer, Justin B., Hyodo, Fuminori, Pendrak, Michael L., Ridnour, Lisa A., DeGraff, William G., Tsokos, Maria, Wink, David A., Roberts, David D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2008
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543077/
https://ncbi.nlm.nih.gov/pubmed/18787106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.080237
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