Activation of PDGF-CC by Tissue Plasminogen Activator Impairs Blood Brain Barrier Integrity During Ischemic Stroke

Thrombolytic treatment of ischemic stroke with tissue plasminogen activator (tPA) is markedly limited due to concerns for hemorrhagic complications and the requirement that tPA be administered within 3 h of symptoms. Here we report that tPA activation of latent platelet-derived growth factor-CC (PDG...

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Detaylı Bibliyografya
Asıl Yazarlar: Su, E. J., Fredriksson, L., Geyer, M., Folestad, E., Cale, J., Andrae, J., Gao, Y, Pietras, K., Mann, K., Yepes, M., Strickland, D. K., Betsholtz, C., Eriksson, U., Lawrence, D. A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811427/
https://ncbi.nlm.nih.gov/pubmed/18568034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1787
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