Activation of PDGF-CC by Tissue Plasminogen Activator Impairs Blood Brain Barrier Integrity During Ischemic Stroke

Thrombolytic treatment of ischemic stroke with tissue plasminogen activator (tPA) is markedly limited due to concerns for hemorrhagic complications and the requirement that tPA be administered within 3 h of symptoms. Here we report that tPA activation of latent platelet-derived growth factor-CC (PDG...

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Detalhes bibliográficos
Main Authors: Su, E. J., Fredriksson, L., Geyer, M., Folestad, E., Cale, J., Andrae, J., Gao, Y, Pietras, K., Mann, K., Yepes, M., Strickland, D. K., Betsholtz, C., Eriksson, U., Lawrence, D. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811427/
https://ncbi.nlm.nih.gov/pubmed/18568034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1787
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