Activation of PDGF-CC by Tissue Plasminogen Activator Impairs Blood Brain Barrier Integrity During Ischemic Stroke

Thrombolytic treatment of ischemic stroke with tissue plasminogen activator (tPA) is markedly limited due to concerns for hemorrhagic complications and the requirement that tPA be administered within 3 h of symptoms. Here we report that tPA activation of latent platelet-derived growth factor-CC (PDG...

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Bibliografische gegevens
Hoofdauteurs: Su, E. J., Fredriksson, L., Geyer, M., Folestad, E., Cale, J., Andrae, J., Gao, Y, Pietras, K., Mann, K., Yepes, M., Strickland, D. K., Betsholtz, C., Eriksson, U., Lawrence, D. A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811427/
https://ncbi.nlm.nih.gov/pubmed/18568034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1787
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