GABA(A) receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice

Individuals with homozygous deficiency in cystathionine-β-synthase (CBS) develop high levels of homocysteine in plasma, a condition known as homocysteinuria. Mental retardation ensues with death in teens; the heterozygous live normally but develop vascular dementia and Alzheimer's disease (AD)...

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Bibliographic Details
Main Authors: Kumar, Munish, Tyagi, Neetu, Moshal, Karni S., Sen, Utpal, Pushpakumar, S.B., Vacek, Thomas, Lominadze, David, Tyagi, Suresh C.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811264/
https://ncbi.nlm.nih.gov/pubmed/18547546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2008.04.021
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