CDC5 Inhibits the Hyperphosphorylation of the Checkpoint Kinase Rad53, Leading to Checkpoint Adaptation

The Saccharomyces cerevisiae polo-like kinase Cdc5 promotes adaptation to the DNA damage checkpoint, in addition to its numerous roles in mitotic progression. The process of adaptation occurs when cells are presented with persistent or irreparable DNA damage and escape the cell-cycle arrest imposed...

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Main Authors: Vidanes, Genevieve M., Sweeney, Frédéric D., Galicia, Sarah, Cheung, Stephanie, Doyle, John P., Durocher, Daniel, Toczyski, David P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811153/
https://ncbi.nlm.nih.gov/pubmed/20126259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000286
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