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Cdc5 blocks in vivo rad53 activity, but not in situ activity (ISA)
DNA damage promotes the activation of a signal transduction cascade referred to as the DNA damage checkpoint. This pathway initiates with the Mec1/ATR kinase, which then phosphorylates the Rad53/Chk2 kinase. Mec1 phosphorylation of Rad53 is then thought to promote Rad53 autophosphorylation, ultimate...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3055179/ https://ncbi.nlm.nih.gov/pubmed/20962588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.21.13637 |
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