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Cdc5 blocks in vivo rad53 activity, but not in situ activity (ISA)

DNA damage promotes the activation of a signal transduction cascade referred to as the DNA damage checkpoint. This pathway initiates with the Mec1/ATR kinase, which then phosphorylates the Rad53/Chk2 kinase. Mec1 phosphorylation of Rad53 is then thought to promote Rad53 autophosphorylation, ultimate...

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Bibliografiske detaljer
Main Authors: Lopez-Mosqueda, Jaime, Vidanes, Genevieve M, Toczyski, David
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055179/
https://ncbi.nlm.nih.gov/pubmed/20962588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.21.13637
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