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Mitochondrial DNA mutations and aging: devils in the details?

Although several lines of evidence support a role for accumulating somatic mitochondrial DNA (mtDNA) mutations in the etiology of aging, it remains unclear if they are a major cause of age-related deterioration and death. Mouse models that harbor elevated mtDNA mutation frequencies age prematurely;...

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Bibliografski detalji
Glavni autori: Khrapko, Konstantin, Vijg, Jan
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811092/
https://ncbi.nlm.nih.gov/pubmed/19110336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2008.11.007
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